Gut bugs could affect kidney disease

Washington, Feb 15 (IANS) Bugs in the gut could have a bearing on how kidney disease, caused by melamine poisoning, turns out, according to a study.

Feb 15 2013, 4:28am CST | by

Gut bugs could affect kidney disease
Photo Credit: SAM PANTHAKY, Getty Images

Washington, Feb 15 — Bugs in the gut could have a bearing on how kidney disease, caused by melamine poisoning, turns out, according to a study.

In 2008, nearly 300,000 Chinese children were hospitalised with kidney disease brought on by powdered milk contaminated with melamine to boost protein content.

Although melamine was known to combine with uric acid in children's bodies to produce harmful kidney stones, details of the reaction and the role of specific gut microbes were not well understood, the journal Science Translational Medicine reports.

Researchers led by Wei Jia at the University of North Carolina studied how melamine contributes to the development of kidney stones in rats.

The formation of kidney stones occurs when melamine reacts with cyanuric acid in the kidneys to form crystals, which cannot be dissolved in the bloodstream.

The study says certain species of gut microbes are responsible for converting melamine into toxic cyanuric acid, thereby accelerating the rate at which kidney stones are formed.

According to a University of North California statement, tests on rats showed that microbes of the Klebsiella family tended to facilitate the process of melamine conversion, potentially making them key players in the formation of kidney stones.

This study suggests that toxicity in this case is linked to the make-up of gut microbes in the poisoned organism.

IANS

Source: IANS

 
 
 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

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