360° Coverage : Asthma drug shows promise in treating diabetes, obesity

Asthma drug shows promise in treating diabetes, obesity

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Feb 11 2013, 3:19am CST | by

Asthma drug shows promise in treating diabetes, obesity
Photo Credit: Spencer Platt, Getty Images

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," says Alan Saltiel, director of the University of Michigan's Life Sciences Institute (LSI), which conducted the study.

"Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice," adds Saltiel.

Different formulations of amlexanox are currently prescribed to treat asthma in Japan and canker sores in the US, the journal Nature Medicine reports.

The study appears to confirm and extend the notion that the genes IKKE and TBK1 play a crucial role for maintaining metabolic balance, a discovery published by the Saltiel lab in 2009, according to an LSI statement.

"Amlexanox appears to work in mice by inhibiting two genes - IKKE and TBK1 - that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less energy."

Using high-throughput chemical screening at LSI's Centre for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.

They then demonstrated that amlexanox had profound beneficial effects in both genetic and dietary-induced obese mice. The chemical lowered the weight of obese mice and reversed related metabolic problems such as diabetes and fatty liver.

IANS

Source: IANS

 
 
 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

blog comments powered by Disqus

Latest stories

Apple TV Rumored to Target Casual Gamers with Motion Sensitive Remote Controls
Apple TV Rumored to Target Casual Gamers with the Motion Sensitive Remote Controls
A report states that the tech giant has been planning to lure the gamers by introducing motion sensitive remote controls for Apple TV.
 
 
12% of Android Users Consider Switch to iPhone 6S
12% of Android Users Consider Switch to iPhone 6S
A new survey shows that 12% of Android users are tempted by the iPhone 6S.
 
 
Apple Reportedly Planning to Introduce iPhone 6C in November 2015
Apple Reportedly Planning to Introduce iPhone 6C in November 2015
A Chinese report states that the successor of the cheaper iPhone 5C will be revealed in the upcoming November.
 
 
iPhone 6S 12MP Camera Confirmed but No Pink
iPhone 6S 12MP Camera Confirmed but No Pink
New reports confirm that the iPhone 6S will adopt a 12MP camera.