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18 hours ago

Sexton Elementary Receives Asthma-Friendly School Award

Source: All Childrens Hospital, St. Petersburg FL | May 24 2013, 12:16pm CDT

The Florida Department of Health (DOH) in Pinellas County honored John M. Sexton Elementary for working with community partners to create a safe and healthy environment for students with asthma. DOH and the Florida Asthma C ...

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2 hours ago

Quote:
"Because the throat is a common pathway for the lungs and the digestive tract, when a person consumes dirty water, the infection can spread to the lower respiratory tract and cause a disease. Persons with allergies including sinusitis, asthma, bronchitis and eosinophilia are more vulnerable"

Source: The Hindu

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Violence and Grief Define Life In Honduran Capital

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Asthma drug shows promise in treating diabetes, obesity

Feb 11 2013, 3:19am CST | by Luigi Lugmayr

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," says Alan Saltiel, director of the University of Michigan's Life Sciences Institute (LSI), which conducted the study.

"Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice," adds Saltiel.

Different formulations of amlexanox are currently prescribed to treat asthma in Japan and canker sores in the US, the journal Nature Medicine reports.

The study appears to confirm and extend the notion that the genes IKKE and TBK1 play a crucial role for maintaining metabolic balance, a discovery published by the Saltiel lab in 2009, according to an LSI statement.

"Amlexanox appears to work in mice by inhibiting two genes - IKKE and TBK1 - that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less energy."

Using high-throughput chemical screening at LSI's Centre for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.

They then demonstrated that amlexanox had profound beneficial effects in both genetic and dietary-induced obese mice. The chemical lowered the weight of obese mice and reversed related metabolic problems such as diabetes and fatty liver.

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