360° Coverage : Asthma drug shows promise in treating diabetes, obesity

1 Updates
Asthma drug shows promise in treating diabetes, obesity
Photo Credit: Spencer Platt, Getty Images

Asthma drug shows promise in treating diabetes, obesity

Feb 11 2013, 3:19am CST | by

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers. "One of the reasons that...

Filed under: news

YouTube Videos

 
 
 

1 year ago

Asthma drug shows promise in treating diabetes, obesity

Feb 11 2013, 3:19am CST | by

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," says Alan Saltiel, director of the University of Michigan's Life Sciences Institute (LSI), which conducted the study.

"Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice," adds Saltiel.

Different formulations of amlexanox are currently prescribed to treat asthma in Japan and canker sores in the US, the journal Nature Medicine reports.

The study appears to confirm and extend the notion that the genes IKKE and TBK1 play a crucial role for maintaining metabolic balance, a discovery published by the Saltiel lab in 2009, according to an LSI statement.

"Amlexanox appears to work in mice by inhibiting two genes - IKKE and TBK1 - that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less energy."

Using high-throughput chemical screening at LSI's Centre for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.

They then demonstrated that amlexanox had profound beneficial effects in both genetic and dietary-induced obese mice. The chemical lowered the weight of obese mice and reversed related metabolic problems such as diabetes and fatty liver.

IANS

Source: IANS

 

Don't miss ...

 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

blog comments powered by Disqus

Latest stories

Drug shows first potential treatment for common anaemia
Washington, Aug 29 (IANS) An experimental drug designed to help regulate the blood's iron supply shows promise as a viable first treatment for anaemia of inflammation.
 
 
Shape-shifting cells behind stripes of zebrafish
London, Aug 29 (IANS) Researchers, including Indian-origin scientists, have discovered how the three major pigment cell types - black, reflective silvery, and yellow cells - arise and behave to form the 'zebra' pattern in zebrafish, a small fresh water fish.
 
 
Junk blood tests may reveal resistant skin bacteria
Washington, Aug 29 (IANS) Instead of trashing contaminated positive blood samples in hospitals, these can be used for studying the presence of skin germs, a study suggests.
 
 
New method to diagnose malaria faster
London, Aug 29 (IANS) Finnish researchers have claimed to develop a new system for diagnosing malaria infection faster.
 
 
 

Latest from the Network

Hardline Nepal Maoists obstruct Indian envoy's programme
Kathmandu, Aug 29 (IANS) Opposing direct Indian investment in Nepal's small development projects, the Communist Party of Nepal-Maoist (CPN-M), a hardline Left entity led by Mohan Baidhya aka Kiran, Friday called a...
Read more on Politics Balla
 
Saina ousted by Olympic champion Li
Copenhagen, Aug 29 (IANS) Saina Nehwal faltered for the fifth consecutive time in the women's singles quarter-finals of the World Badminton Championships when she was ousted in straight games by top seeded Chinese Li...
Read more on Sport Balla
 
Malaysia Airlines to cut 6,000 jobs
Kuala Lumpur, Aug 29 (IANS) Malaysia Airlines (MAS) is set to slash 6,000 jobs and cut routes as part of a major revamp after suffering the loss of two commercial jets this year, the Straits Times reported Friday....
Read more on Business Balla
 
Jessica Chastain demands a female superhero movie
Jessica Chastain wants to see the release of a female superhero movie. The acclaimed actress, who starred in the 2013 horror film 'Mama', says Marvel Studios should make a movie in which Scarlett Johansson and her Black...
Read more on Movie Balla
 
New characters to join 'Avengers'
New characters are set to join the 'Avengers'. According to Badass Digest, the latest movie in the franchise 'Avengers: Age Of Ultron' will finish with Captain America creating a new team of superheroes by combining the...
Read more on Movie Balla
 
David Brent movie is almost a musical, says Ricky Gervais
Ricky Gervais says the new David Brent movie is ''almost a musical''. The comedian has given fans of the TV character a preview of what they can expect from the much-hyped film, revealing that it'll take the shape of...
Read more on Movie Balla
 
Joaquin Phoenix in 'final talks' for Doctor Strange
Joaquin Phoenix is reportedly in final talks to play Doctor Strange in a new Marvel movie. The Academy Award nominated actor is rumoured to be the top choice for the superhero role in the latest Marvel blockbuster,...
Read more on Movie Balla
 
Drug shows first potential treatment for common anaemia
Washington, Aug 29 (IANS) An experimental drug designed to help regulate the blood's iron supply shows promise as a viable first treatment for anaemia of inflammation. The present treatment strategy for anaemia of...
Read more on Apple Balla
 
Shape-shifting cells behind stripes of zebrafish
London, Aug 29 (IANS) Researchers, including Indian-origin scientists, have discovered how the three major pigment cell types - black, reflective silvery, and yellow cells - arise and behave to form the 'zebra' pattern...
Read more on Apple Balla
 
Beware! Married couple share most bacteria
Washington, Aug 29 (IANS) Know where do bacteria reign? In the cosiness of your home - at doorknobs, light switches, floors, countertops - and within relationships. If you are married and have kids, you tend to share...
Read more on Business Balla