360° Coverage : Asthma drug shows promise in treating diabetes, obesity

1 Updates
Asthma drug shows promise in treating diabetes, obesity
Photo Credit: Spencer Platt, Getty Images

Asthma drug shows promise in treating diabetes, obesity

Feb 11 2013, 3:19am CST | by

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers. "One of the reasons that...

Filed under: news

YouTube Videos

 
 
 

1 year ago

Asthma drug shows promise in treating diabetes, obesity

Feb 11 2013, 3:19am CST | by

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," says Alan Saltiel, director of the University of Michigan's Life Sciences Institute (LSI), which conducted the study.

"Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice," adds Saltiel.

Different formulations of amlexanox are currently prescribed to treat asthma in Japan and canker sores in the US, the journal Nature Medicine reports.

The study appears to confirm and extend the notion that the genes IKKE and TBK1 play a crucial role for maintaining metabolic balance, a discovery published by the Saltiel lab in 2009, according to an LSI statement.

"Amlexanox appears to work in mice by inhibiting two genes - IKKE and TBK1 - that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less energy."

Using high-throughput chemical screening at LSI's Centre for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.

They then demonstrated that amlexanox had profound beneficial effects in both genetic and dietary-induced obese mice. The chemical lowered the weight of obese mice and reversed related metabolic problems such as diabetes and fatty liver.

IANS

Source: IANS

 

Don't miss ...

 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

blog comments powered by Disqus

Latest stories

ASUS MeMO Pad 7 Intel Bay Trail Tablet Shows Serious Android On X86 Value
ASUS MeMO Pad 7 Intel Bay Trail Tablet Shows Serious Android On X86 Value
Low cost tablets have been a goal for a long time now but breaking the $200 mark hasn’t been easy for manufacturers, without sacrificing features and quality.  Then again, what if I told you there’s a 7-inch tablet on...
 
 
Massive increase in R&D spending suggests awesome new Apple products are on the way
Massive increase in R&D spending suggests awesome new Apple products are on the way
It’s been a long time since Apple had anything to prove in the mobile world, but as iPhone iterations have become increasingly indistinguishable from one another, the Cupertino crew realized it might be time to catch...
 
 
Purported iPhone 6 parts leak suggests two different models are indeed in the works
Purported iPhone 6 parts leak suggests two different models are indeed in the works
A new set of images showing alleged iPhone 6 internal components seems to prove Apple is indeed working on a couple of different iPhone models that will launch later this year. The new pictures, posted on Apple.club.tw...
 
 
4 more awesome paid iPhone apps that are free right now
4 more awesome paid iPhone apps that are free right now
Before the sun sets on another week, we have one last batch of paid iPhone and iPad apps to share with you that are currently on sale for free for a limited time. This has been a terrific week for thrifty app shoppers...
 
 
 

Latest from the Network

Love the idea of lots of kids: Radcliffe
New York, July 26 (IANS) If Daniel Radcliffe had his way, he'd have "lots of kids" in the years to come. "Maybe because I'm an only child, I love the idea of lots of kids. But it will depend to a larger part on who I...
Read more on Celebrity Balla
 
Kyrgyz ex-president sentenced to life imprisonment
Bishkek, July 26 (IANS) A Kyrgyz military court Friday sentenced in absentia the country's former president Kurmanbek Bakiyev, his brother Janysh Bakiyev and former prime minister Daniyar Usenov to life imprisonment....
Read more on Politics Balla
 
Why Lily Allen goes into shutdown mode?
Los Angeles, July 26 (IANS) Singer Lily Allen has decided to go into shutdown mode after receiving criticism on a social networking site. Allen says this is her way of coping with backlash, reports mirror.co.uk. The...
Read more on Celebrity Balla
 
ASUS MeMO Pad 7 Intel Bay Trail Tablet Shows Serious Android On X86 Value
Low cost tablets have been a goal for a long time now but breaking the $200 mark hasn’t been easy for manufacturers, without sacrificing features and quality.  Then again, what if I told you there’s a 7-inch tablet on...
Read more on Apple Balla
 
Five policemen killed in Al Qaeda attack in Yemen
Sanaa, July 26 (IANS) At least five Yemeni policemen were killed Friday evening when suspected Al Qaeda gunmen attacked a security checkpoint in the southeastern province of al-Bayda, an interior ministry official said...
Read more on Politics Balla
 
China pledges more support for Afghanistan's development
Kabul, July 26 (IANS) China would like to see a smooth transition of power in Afghanistan and will give more support for the country's reconciliation and economic development, China's newly-appointed Special Envoy for...
Read more on Politics Balla
 
Elton John reveals secrets for biopic
Los Angeles, July 26 (IANS) Singer Elton John has revealed the secrets of his rehab diaries for his upcoming biopic featuring Tom Hardy. Hardy is all geared up to portray the 67-year-old musician in the biopic, which...
Read more on Celebrity Balla
 
Joint efforts on in Cairo to reach ceasefire in Gaza
Cairo, July 26 (IANS) Egypt, the UN, the Arab League and the US are working together to reach a seven-day "humanitarian ceasefire" for the ongoing conflict between Israel and Gaza-ruling Hamas movement, Egyptian...
Read more on Politics Balla
 
Massive increase in R&D spending suggests awesome new Apple products are on the way
It’s been a long time since Apple had anything to prove in the mobile world, but as iPhone iterations have become increasingly indistinguishable from one another, the Cupertino crew realized it might be time to catch...
Read more on Apple Balla
 
China denounces British parliament's inquiry
Beijing, July 26 (IANS) China Friday urged Britain to stop interfering in Hong Kong affairs after a British parliamentary committee conducted an inquiry on the implementation of a Hong Kong joint declaration. "Such...
Read more on Politics Balla