360° Coverage : Asthma drug shows promise in treating diabetes, obesity

1 Updates
Asthma drug shows promise in treating diabetes, obesity
Photo Credit: Spencer Platt, Getty Images

Asthma drug shows promise in treating diabetes, obesity

Feb 11 2013, 3:19am CST | by

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers. "One of the reasons that...

Filed under: news

YouTube Videos

 
 
 

1 year ago

Asthma drug shows promise in treating diabetes, obesity

Feb 11 2013, 3:19am CST | by

Washington, Feb 11 (IANS) Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

Washington, Feb 11 — Amlexanox, a drug prescribed for asthma in Japan, also reverses obesity, diabetes and fatty liver in mice, according to a new study by US researchers.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," says Alan Saltiel, director of the University of Michigan's Life Sciences Institute (LSI), which conducted the study.

"Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice," adds Saltiel.

Different formulations of amlexanox are currently prescribed to treat asthma in Japan and canker sores in the US, the journal Nature Medicine reports.

The study appears to confirm and extend the notion that the genes IKKE and TBK1 play a crucial role for maintaining metabolic balance, a discovery published by the Saltiel lab in 2009, according to an LSI statement.

"Amlexanox appears to work in mice by inhibiting two genes - IKKE and TBK1 - that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less energy."

Using high-throughput chemical screening at LSI's Centre for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.

They then demonstrated that amlexanox had profound beneficial effects in both genetic and dietary-induced obese mice. The chemical lowered the weight of obese mice and reversed related metabolic problems such as diabetes and fatty liver.

IANS

Source: IANS

 

Don't miss ...

 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

blog comments powered by Disqus

Latest stories

Apple Black Friday Deals are on Sale in MacMall Black Friday 2014 Sale
 
 
The Black Friday 2014 Sales You can Shop Today 11/26
The Black Friday 2014 Sales You can Shop Today 11/26
Over 20 Black Friday 2014 sales are already launched. Get the deals early to get your head free for the hard to get Black Friday deals to be released on Thanksgiving Day.
 
 
Target Black Friday Pre Sale launched Online
Target Black Friday Pre Sale launched Online
The Target Black Friday 2014 pre sale is live online offering $100 Gift Cards with iPad Air and iPad mini 3 purchases and many more deals.
 
 
The Best Black Friday 2014 iPad Deals
The Best Black Friday 2014 iPad Deals
The Amazon Black Friday 2014 Sale has been released. The Amazon Black Friday 2014 begins earlier than ever before. In past years the Amazon Black Friday deals week started on Sunday.Besides Amazon, Walmart has kicked...
 
 
 

Latest from the Network

Modi, Sharif bonhomie gives fresh boost to Saarc (Roundup)
Kathmandu, Nov 27 (IANS) In a final ice-breaking moment, that gave a huge boost to Saarc and floundering regional cooperation, Indian Prime Minister Narendra Modi shook hands with his Pakistani counterpart Nawaz Sharif...
Read more on Politics Balla
 
Now, flying robots to serve as waiters in Singapore
Singapore, Nov 27 (IANS) If you are planning to visit Singapore next year, don't be surprised if you were greeted and served a sumptuous meal by flying robots as waiters in some restaurants. Infinium-Serve, the...
Read more on Politics Balla
 
Four Afghans, one Briton killed in Kabul suicide attack
Kabul, Nov 27 (IANS/EFE) A British national and four Afghans were killed Thursday in a suicide attack on a British embassy vehicle in Kabul which left 34 others injured, officials said. The attack occurred at 10.30 a....
Read more on Politics Balla
 
Badminton to continue testing of five-game scoring system
Kuala Lumpur, Nov 27 (IANS) The Badminton World Federation (BWF) Thursday decided to continue with the testing variations of the best of five games. "Following the recent BWF Council meeting in Lima, Peru, members...
Read more on Sport Balla
 
Two arrested in France for jihadi propaganda
Paris, Nov 27 (IANS) French police arrested a couple in Ain, central east France on charges of belonging to an alleged jihadi propaganda network, media reported on Thursday. A French man in his thirties, who converted...
Read more on Politics Balla
 
Japanese court rejects lawsuit against reopening two n-plants
Tokyo, Nov 27 (IANS/EFE) A Japanese court Thursday rejected a class action lawsuit filed by residents of the western prefecture of Shiga against reactivating offline nuclear power plants in Takahama and Oi. The ruling...
Read more on Politics Balla
 
SJVNL signs pact with Nepal for hydro-power plant
Kathmandu, Nov 27 (IANS) Indian public sector company Satluj Jal Vidyut Nigam Ltd. (SJVNL) has signed a project development agreement with the Nepal government for executing the 900 MW Arun-III Hydro Electric Project...
Read more on Business Balla
 
13 civilians killed by Ukrainian forces: Separatists
Moscow, Nov 27 (IANS/EFE) At least 13 civilians were killed in recent shelling by Ukrainian artillery in the eastern city of Donetsk controlled by pro-Russian separatists, the rebel command announced Thursday. A...
Read more on Politics Balla
 
Zambian police gear up for presidential election
Lusaka, Nov 27 (IANS) Police in Zambia have stepped up measures to ensure peace ahead of a presidential election scheduled for Jan 20, a top official said Thursday. Stella Libongani, the inspector general of Zambia...
Read more on Politics Balla
 
Hong Kong students threaten to occupy government buildings
Hong Kong, Nov 27 (IANS/EFE) Students participating in the pro-democracy demonstrations in Hong Kong threatened Thursday to attack government buildings following a night of clashes that occurred just hours after the...
Read more on Politics Balla